Exploratory clinical trial: Topical probiotic strain reduces wrinkles and pigmentation.

In this published study in Journal of Cosmetic Dermatology, an exploratory clinical trial was conducted to investigate the anti-aging potential of a cosmetic probiotic ointment containing live Lactiplantibacillus plantarum LB244R® for topical application.
Anti-aging efficacy on facial skin was evaluated by assessing 10 parameters; SLEB thickness, dermal density, skin firmness and elasticity, skin hydration, TEWL, crow's feet wrinkles, spots, smoothness, and complexion radiance and comparing them to baseline measurements. The topical application of Lactiplantibacillus plantarum LB244R® improved all measured anti-age parameters with statistical significance.
Lactic acid bacteria (LAB) are commonly used in probiotics and have been widely studied in different human applications, albeit the topical use of viable LAB remains in its infancy as compared to the orally applied probiotics.
Topical application of certain probiotics has proven ability to affect/modulate dysbiotic microbiomes and thereby affect disease phenotypes. Currently, diseases in which probiotics can have a positive effect include psoriasis, atopic dermatitis, acne vulgaris, seborrheic dermatitis, and rosacea. Lactiplantibacillus plantarum LB244R® was originally selected for topical use due to its antibacterial activity toward Staphylococcus aureus clonal type 1 and its ability to positively alleviate symptoms of atopic skin but has since been suspected to also positively influence aging skin.
 
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Also featured and interview in Cosmetics Design:  https://www.cosmeticsdesign.com/Article/2023/02/08/Topical-probiotic-has-anti-aging-benefits-study-confirms